Conditional probability as found in nature: Facilitated diffusion

نویسندگان

چکیده

Search processes are ubiquitous in physical and biological phenomena, often involving the random motion of molecules. In particular, transcription factors (TFs) proteins that regulate gene expression need to find their DNA targets quickly—which is difficult achieve with alone. Nature came up a remarkable solution known as facilitated diffusion, combining 1D diffusion along “excursions” 3D help TF quickly arrive at distant parts DNA. this paper, we show process can be analyzed naturally using concept conditional probability, providing an alternative intuition effectiveness mechanism.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Induction as conditional probability judgment.

Existing research on category-based induction has primarily focused on reasoning about blank properties, or predicates that are designed to elicit little prior knowledge. Here, we address reasoning about nonblank properties. We introduce a model of conditional probability that assumes that the conclusion prior probability is revised to the extent warranted by the evidence in the premise. The de...

متن کامل

Conditional Probability

A fair die is about to be tossed. The probability that it lands with ‘5’ showing up is 1/6; this is an unconditional probability. But the probability that it lands with ‘5’ showing up, given that it lands with an odd number showing up, is 1/3; this is a conditional probability. In general, conditional probability is probability given some body of evidence or information, probability relativised...

متن کامل

Lexicographic probability, conditional probability, and nonstandard probability

The relationship between Popper spaces (conditional probability spaces that satisfy some regularity conditions), lexicographic probability systems (LPS’s) [Blume, Brandenburger, and Dekel 1991a; Blume, Brandenburger, and Dekel 1991b], and nonstandard probability spaces (NPS’s) is considered. If countable additivity is assumed, Popper spaces and a subclass of LPS’s are equivalent; without the as...

متن کامل

In Vivo Facilitated Diffusion Model

Under dilute in vitro conditions transcription factors rapidly locate their target sequence on DNA by using the facilitated diffusion mechanism. However, whether this strategy of alternating between three-dimensional bulk diffusion and one-dimensional sliding along the DNA contour is still beneficial in the crowded interior of cells is highly disputed. Here we use a simple model for the bacteri...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: American Journal of Physics

سال: 2023

ISSN: ['0002-9505', '1943-2909']

DOI: https://doi.org/10.1119/5.0123866